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Effects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women BJMBR
Pereira,D.S.; Garcia,D.M.; Narciso,F.M.S.; Santos,M.L.A.S.; Dias,J.M.D.; Queiroz,B.Z.; Souza,E.R.; Nóbrega,O.T.; Pereira,L.S.M..
We investigated the effect of -174 G/C single-nucleotide polymorphism in the promoter region of the IL6 gene on plasma IL-6 levels and muscle strength, and the relationship between IL-6 levels and muscle strength in elderly women. The sample consisted of 199 elderly residents (73.0 ± 7.8 years old) from rest homes and the community in Belo Horizonte, MG, Brazil. -174 G/C polymorphism was determined by direct sequencing of the product by PCR, and plasma IL-6 concentrations were measured by ELISA. Muscle strength in the knee joint was evaluated using a Biodex System 3 Pro® isokinetic dynamometer. ANCOVA was used to determine the effect of polymorphism on IL-6 levels and muscle strength, and the Pearson correlation coefficient to assess the relationship...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Interleukin-6; Elderly; Muscular strength; 174 G/C polymorphism.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200006
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Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration BJMBR
Ribeiro-Samora,G.A.; Rabelo,L.A.; Ferreira,A.C.C.; Favero,M.; Guedes,G.S.; Pereira,L.S.M.; Parreira,V.F.; Britto,R.R..
Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Blood analysis was performed before exercise (baseline),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Inflammation; Oxidative stress; Exercise intensity; Exercise duration.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900608
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Muscle strength but not functional capacity is associated with plasma interleukin-6 levels of community-dwelling elderly women BJMBR
Oliveira,D.M.G.; Narciso,F.M.S.; Santos,M.L.A.S.; Pereira,D.S.; Coelho,F.M.; Dias,J.M.D.; Pereira,L.S.M..
The association of plasma interleukin-6 (IL-6) levels, muscle strength and functional capacity was investigated in a cross-sectional study of community-dwelling elderly women from Belo Horizonte, Brazil. Elderly people who present controlled chronic diseases with no negative impact on physical, psychosocial and mental functionality are considered to be community-dwelling. Psychological and social stress due to unsuccessfully aging can represent a risk for immune system disfunctions. IL-6 levels, isokinetic muscle strength of knee flexion/extension, and functional tests to determine time required to rise from a chair and gait velocity were measured in 57 participants (71.21 ± 7.38 years). Serum levels of IL-6 were measured in duplicate and were performed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Muscle strength; Interleukin-6; Elderly women; Sarcopenia; Aging; IL-6.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200017
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Muscular function and functional mobility of faller and non-faller elderly women with osteoarthritis of the knee BJMBR
Alencar,M.A.; Arantes,P.M.M.; Dias,J.M.D.; Kirkwood,R.N.; Pereira,L.S.M.; Dias,R.C..
Falls are a major concern in the elderly population with chronic joint disease. To compare muscular function and functional mobility among older women with knee osteoarthritis with and without a history of falls, 15 elderly women with a history of falls (74.20 ± 4.46 years) and 15 without a history of falls (71.73 ± 4.73 years) were studied. Muscular function, at the angular speed of 60, 120, and 180º/s, was evaluated using the Biodex Isokinetic Dynamometer. The sit-to-stand task was performed using the Balance Master System and the Timed Up and Go test was used to determine functional mobility. After collection of these data, the history of falls was investigated. A statistically significant difference was detected in the time taken to transfer the center...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Elderly women; Falls; Knee osteoarthritis; Muscular function; Functional performance.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200016
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Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats BJMBR
Yokoro,C.M.; Tatsuo,M.A.K.F.; Pereira,L.S.M.; Alves,D.L.F.; Francischi,J.N..
We compared the intensity and frequency of arthritis in old (8-12 months, N = 12) and juvenile (2 months, N = 10) rats and determined the role played by adrenal glands in this disorder. Arthritis was induced by subcutaneous injection of Mycobacterium butyricum at the base of the tail of female Holtzman rats at day zero. Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. Some (N = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. All bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. Hyperalgesia and paw edema responses were less...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Edema; Adjuvant arthritis; Adrenalectomy; Dexamethasone; Old rats.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100011
Registros recuperados: 5
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